The Sativa high is often characterized as uplifting and energetic. The effects of a Sativa marijuana are mostly cerebral. They give a feeling of optimism and well - being, as well as providing a good measure of pain relief for certain symptoms. A few pure Sativa strains are also very high in THC content. They are known to have a quite spacey, or hallucinogenic, effect. Sativa strains are a wise choice for daytime smoking.